| 18:00 | Chievo  Juventus |  |
| 18:00 | Lokeren  Standard de Liège |  |
| 18:15 | Celta Vigo  Espanyol |  |
| 18:30 | Chelsea  Arsenal |  |
| 20:00 | Stade Rennais  Angers |  |
| 20:00 | Monaco  Lille |  |
| 20:00 | Amiens SC  Montpellier |  |
| 20:00 | Dijon  Nantes |  |
| 20:00 | Caen  Nice |  |
| 20:15 | Villarreal  Real Sociedad | |
| 20:30 | Lazio  Naples | |
| 20:45 | Fortuna Sittard  PSV | |
| 20:45 | Yeni Malatyaspor  Fenerbahçe |  |
| 22:15 | FC Barcelone  Deportivo Alavés |  |
| 01:00 | Whitecaps  New York RB |  |
| 01:00 | Philadelphie Union  New York City | |
| 01:30 | Montréal Impact  Chicago Fire | |
| 02:00 | Dallas  Minnesota United | |
| 02:30 | Sporting KC  Portland Timbers | |
| 14:30 | Manchester City  Huddersfield Town | |
| 15:00 | Strasbourg  Saint-Étienne | |
| 17:00 | Brighton & Hove Albion  Manchester United | |
| 17:00 | Toulouse  Bordeaux | |
| 18:00 | Torino  AS Roma | |
| 18:00 | Genk  Sporting Charleroi | |
| 18:15 | BB Erzurumspor  Besiktas | |
| 18:15 | Eibar  Huesca | |
| 20:15 | Rayo Vallecano  FC Séville | |
| 20:30 | Bologne  SPAL | |
| 20:30 | Parme  Udinese | |
| 20:30 | Empoli  Cagliari | |
| 20:30 | Sassuolo  Internazionale | |
| 20:30 | Milan AC  Genoa | |
| 20:30 | Sampdoria  Fiorentina | |
| 20:45 | Galatasaray  Goztepe AS Izmir | |
| 21:00 | Nîmes  Olympique de Marseille |  |
| 22:00 | Atlanta United  Columbus Crew |  |
| 22:15 | Real Madrid  Getafe | |
| 01:30 | DC United  New England | |
| 04:00 | Los Angeles FC  Colorado Rapids | |
| 20:00 | Valence  Atlético Madrid | |
| 20:45 | Metz  AC Ajaccio |  |
| 21:00 | Crystal Palace  Liverpool | |
| 22:00 | Athletic Bilbao  Leganes | |
| 01:00 | New York CityNew York RB | |