| 18:55 | RB Leipzig  Zenit |  |
| 18:55 | Ajax  Chelsea |  |
| 21:00 | Genk  Liverpool |  |
| 21:00 | Salzbourg  Naples |  |
| 21:00 | Lille  Valence | |
| 21:00 | Benfica  Olympique Lyonnais | |
| 21:00 | Slavia Prague  FC Barcelone |  |
| 21:00 | Inter Milan  Borussia Dortmund |  |
| 18:55 | SK Slovan Bratislava  Wolverhampton Wanderers | |
| 18:55 | AZ  Astana |  |
| 18:55 | CSKA Moscou  Ferencváros |  |
| 18:55 | Partizan  Manchester United | |
| 18:55 | Qarabağ  APOEL |  |
| 18:55 | Ludogorets  Espanyol |  |
| 18:55 | Besiktas  Sporting Braga |  |
| 18:55 | Istanbul BB  Wolfsberger AC |  |
| 18:55 | Saint-Étienne  Oleksandria |  |
| 18:55 | La Gantoise  Wolfsbourg |  |
| 18:55 | FC Porto  Glasgow Rangers FC | |
| 18:55 | AS Roma  Borussia M'gladbach | |
| 18:55 | Young Boys  Feyenoord | |
| 21:00 | FC Séville  F91 Dudelange | |
| 21:00 | Getafe  FC Bâle | |
| 21:00 | Sporting CP  Rosenborg | |
| 21:00 | Eintracht Francfort  Standard de Liège | |
| 21:00 | Arsenal  Vitoria Guimaraes | |
| 21:00 | Trabzonspor  Krasnodar | |
| 21:00 | Stade Rennais  CFR 1907 Cluj | |
| 21:00 | PSV  Linzer ASK | |
| 21:00 | Celtic Glasgow FC  Lazio | |
| 21:00 | FC Dynamo Kiev  Copenhague | |
| 21:00 | Malmö FF  Lugano | |
| 20:00 | Sochaux  AC Ajaccio |   |
| 20:00 | Le Mans  Niort |  |
| 20:00 | Nancy  Lens |  |
| 20:00 | Rodez  Chambly |  |
| 20:00 | Guingamp  Clermont |  |
| 20:00 | AJ Auxerre  Grenoble Foot 38 |  |
| 20:00 | Paris FC  Caen |  |
| 20:00 | Orléans  Châteauroux |  |
| 20:30 | AS Eupen  Anderlecht |  |
| 20:45 | Nantes  Monaco |  |
| 21:00 | Southampton  Leicester City |  |
| - | FC Barcelone Real Madrid | |
| 13:30 | Manchester City  Aston Villa |  |
| 15:00 | Lecce  Juventus |  |
| 15:00 | Lorient  Troyes | |
| 15:30 | Bayern Munich  Union Berlin | |
| 15:30 | Fribourg RB Leipzig | |
| 15:30 | Schalke 04 Borussia Dortmund | |
| 16:00 | Leganes  Majorque | |
| 17:30 | Lille Bordeaux | |
| 18:00 | Inter Milan Parme | |
| 18:30 | Burnley Chelsea | |
| 20:00 | Brest  Dijon | |
| 20:00 | Strasbourg  Nice | |
| 20:00 | Montpellier  Angers | |
| 20:00 | Olympique Lyonnais Metz | |
| 20:00 | Reims  Nîmes | |
| 21:00 | Atlético Madrid  Athletic Bilbao | |
| 12:00 | Celta Vigo  Real Sociedad | |
| 14:00 | Grenade  Bétis Séville | |
| 15:00 | Stade Rennais Toulouse | |
| 15:00 | Newcastle United Wolverhampton Wanderers | |
| 15:00 | SPAL Naples | |
| 16:00 | Tondela Benfica | |
| 16:00 | Levante Espanyol | |
| 16:45 | AjaxFeyenoord |  |
| 17:00 | Saint-Étienne Amiens SC | |
| 17:00 | Besiktas Galatasaray | |
| 17:30 | Liverpool Tottenham Hotspur | |
| 18:00 | Borussia M'gladbachEintracht Francfort | |
| 18:00 | AS Roma Milan AC | |
| 18:30 | FC SévilleGetafe | |
| 18:30 | FC Porto Famalicão | |
| 20:45 | Fiorentina Lazio | |
| 21:00 | PSG  Olympique de Marseille | |
| 21:00 | Osasuna Valence | |
| 21:00 | Sporting CPVitoria Guimaraes | |
| 20:45 | Valenciennes  Le Havre | |
| 18:45 | NîmesLens | |
| 19:00 | Deportivo Alavés Atlético Madrid | |
