| 18:55 | Dinamo Zagreb  Manchester City |  |
| 18:55 | FC Shakhtar Donetsk  Atalanta |  |
| 21:00 | Bayern Munich  Tottenham Hotspur | |
| 21:00 | Bayer Leverkusen  Juventus |  |
| 21:00 | Club Bruges  Real Madrid |  |
| 21:00 | Atlético Madrid  Lokomotiv Moscou |  |
| 21:00 | PSG  Galatasaray | |
| 21:00 | Olympiakos Pirée  Étoile rouge de Belgrade |  |
| 18:55 | Standard de Liège  Arsenal | |
| 18:55 | APOEL  FC Séville | |
| 18:55 | Eintracht Francfort  Vitoria Guimaraes | |
| 18:55 | Stade Rennais  Lazio | |
| 18:55 | Linzer ASK  Sporting CP |  |
| 18:55 | CFR 1907 Cluj  Celtic Glasgow FC | |
| 18:55 | Getafe  Krasnodar |  |
| 18:55 | FC Dynamo Kiev  Lugano |  |
| 18:55 | PSV  Rosenborg | |
| 18:55 | Copenhague  Malmö FF |  |
| 18:55 | Qarabağ  F91 Dudelange |  |
| 18:55 | FC Bâle  Trabzonspor |  |
| 21:00 | La Gantoise  Oleksandria | |
| 21:00 | Ludogorets  Ferencváros | |
| 21:00 | Glasgow Rangers FC  Young Boys | |
| 21:00 | FC Porto  Feyenoord | |
| 21:00 | Borussia M'gladbach  Istanbul BB | |
| 21:00 | Wolfsbourg  Saint-Étienne | |
| 21:00 | Wolverhampton Wanderers  Besiktas | |
| 21:00 | Espanyol  CSKA Moscou | |
| 21:00 | Partizan  Astana | |
| 21:00 | AS Roma  Wolfsberger AC | |
| 21:00 | SK Slovan Bratislava  Sporting Braga | |
| 21:00 | Manchester United  AZ | |
| 18:00 | Dunkerque  Boulogne |  |
| 20:00 | Gazélec Ajaccio  Béziers |  |
| 20:00 | Bourg-Péronnas  Cholet | |
| 20:00 | Red Star  Quevilly | |
| 20:00 | Clermont  Le Havre |  |
| 20:00 | Toulon  Lyon-Duchère | |
| 20:00 | Lorient  AJ Auxerre |  |
| 20:00 | Sochaux  Grenoble Foot 38 |  |
| 20:00 | Rodez  Caen |  |
| 20:00 | Nancy  Châteauroux |  |
| 20:00 | Villefranche  Bastia-Borgo | |
| 20:00 | Créteil  Concarneau | |
| 20:00 | Laval  Avranches | |
| 20:00 | Le Mans  Orléans | |
| 20:00 | Chambly  Niort |  |
| 20:00 | Valenciennes  Paris FC |  |
| 20:45 | Lille  Montpellier | |
| 13:00 | Grenade  Levante | |
| 13:30 | Birmingham City  West Bromwich Albion |  |
| 13:30 | Liverpool  Watford |  |
| 15:00 | Brescia  Lecce | |
| 15:00 | AC Ajaccio  Lens |  |
| 15:30 | Bayern Munich Werder Brême | |
| 15:30 | Mainz 05  Borussia Dortmund | |
| 15:30 | Hertha BSC  Fribourg | |
| 16:00 | Real Sociedad  FC Barcelone | |
| 16:00 | Chelsea  Bournemouth | |
| 17:30 | Metz  Olympique de Marseille | |
| 18:00 | Galatasaray Ankaragücü | |
| 18:00 | Antwerp  AS Eupen |  |
| 18:00 | Naples  Parme | |
| 18:30 | Fortuna Düsseldorf  RB Leipzig | |
| 18:30 | Southampton  West Ham United | |
| 19:00 | Pau  Le Puy | |
| 20:00 | Amiens SC  Dijon | |
| 20:00 | Toulouse  Reims | |
| 20:00 | Nîmes  Nantes | |
| 20:00 | Brest  Nice | |
| 20:00 | Angers  Monaco | |
| 20:45 | Genoa  Sampdoria | |
| 21:00 | Atlético Madrid Osasuna | |
| 12:00 | Getafe Real Valladolid | |
| 12:30 | Hellas Verone  Torino | |
| 14:00 | Celta Vigo  Majorque | |
| 14:30 | FeyenoordPSV | |
| 14:30 | Sivasspor  Fenerbahçe | |
| 15:00 | Juventus Udinese | |
| 15:00 | Bologne Atalanta | |
| 15:00 | Milan AC  Sassuolo | |
| 15:00 | Bordeaux  Strasbourg | |
| 15:30 | WolfsbourgBorussia M'gladbach | |
| 16:00 | Espanyol Bétis Séville | |
| 16:45 | AZ Ajax |  |
| 17:00 | Besiktas Yeni Malatyaspor | |
| 17:00 | Olympique Lyonnais Stade Rennais | |
| 17:30 | ArsenalManchester City | |
| 18:00 | Schalke 04 Eintracht Francfort | |
| 18:00 | AS Roma SPAL | |
| 18:30 | FC Séville Villarreal | |
| 20:45 | Fiorentina  Inter Milan | |
| 21:00 | Valence Real Madrid | |
| 21:00 | Saint-ÉtiennePSG | |
| 20:45 | Crystal Palace  Brighton & Hove Albion | |
| 20:45 | Guingamp  Troyes |  |
| 18:45 | ReimsMontpellier | |
| 20:30 | Borussia DortmundRB Leipzig | |
| 20:45 | Aston Villa Liverpool | |
| 21:05 | MonacoLille | |
