| 15:30 | Borussia Dortmund  Augsbourg |  |
| 15:30 | Fribourg  Mainz 05 |  |
| 15:30 | Werder Brême  Fortuna Düsseldorf |  |
| 15:30 | Wolfsbourg  Cologne |  |
| 15:30 | Bayer Leverkusen  Paderborn |  |
| 16:00 | Southampton  Liverpool |   |
| 16:00 | Nottingham Forest  Birmingham City |  |
| 17:00 | Celta Vigo  Real Madrid |  |
| 17:30 | Nantes  Olympique de Marseille |  |
| 18:00 | Courtrai  Anderlecht |  |
| 18:30 | Manchester City  Tottenham Hotspur | |
| 18:30 | VVV  Ajax |  |
| 18:30 | Borussia M'gladbach  Schalke 04 | |
| 19:00 | Valence  Real Sociedad | |
| 20:00 | Metz  Monaco | |
| 20:00 | Nîmes  Nice | |
| 20:00 | Belenenses  Benfica |  |
| 20:00 | Bordeaux  Montpellier | |
| 20:00 | Toulouse  Dijon | |
| 20:00 | Amiens SC  Lille |  |
| 20:45 | Sivasspor  Besiktas | |
| 21:00 | Leganes  Osasuna | |
| 21:00 | Villarreal  Grenade |  |
| 22:30 | FC Porto  Vitoria Sétubal | |
| 01:00 | New York RB  New England | |
| 01:30 | Columbus Crew  Toronto | |
| 01:30 | Montréal Impact  Dallas | |
| 02:00 | Chicago Fire  Philadelphie Union | |
| 04:00 | LA Galaxy  Seattle Sounders | |
| 14:30 | Standard de Liège  Royal Excel Mouscron | |
| 15:00 | Saint-Étienne  Brest | |
| 15:00 | Sheffield United  Crystal Palace | |
| 15:30 | Eintracht Francfort  Hoffenheim | |
| 16:45 | Feyenoord  Utrecht | |
| 17:00 | Deportivo Alavés  Levante | |
| 17:00 | Reims  Strasbourg | |
| 17:30 | Chelsea  Leicester City | |
| 18:00 | Union Berlin  RB Leipzig | |
| 19:00 | Espanyol  FC Séville | |
| 21:00 | Bétis Séville  Real Valladolid | |
| 21:00 | Stade Rennais  PSG | |
| 22:00 | Sporting CP  Sporting Braga | |
| 22:00 | Atlético Madrid  Getafe | |
| 04:00 | Portland Timbers  Atlanta United | |
| 19:00 | Fenerbahçe  Gaziantep BB | |
| 20:45 | AJ Auxerre  Guingamp |  |
| 21:00 | Wolverhampton Wanderers  Manchester United | |
| 20:30 | StrasbourgEintracht Francfort | |
| 20:00 | Clermont AJ Auxerre | |
| 20:00 | Chambly  Châteauroux | |
| 20:00 | Le Havre  Grenoble Foot 38 | |
| 20:00 | AC Ajaccio  Paris FC | |
| 20:00 | Le Mans  Lorient | |
| 20:00 | Sochaux  Nancy | |
| 20:00 | Rodez  Orléans | |
| 20:00 | Niort  Caen | |
| 20:30 | CologneBorussia Dortmund |  |
| 21:00 | Aston Villa  Everton | |
| 22:00 | LevanteVillarreal | |
| 13:30 | Norwich City Chelsea | |